USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P28070 USC-OGP 2-DE database:  P28070 P28070 General information about the entry View entry in simple text format Entry name PSB4_HUMAN Primary accession number P28070 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-4; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=26 kDa prosomal protein; Short=HsBPROS26; Short=PROS-26; AltName: Full=Macropain beta chain; AltName: Full=Multicatalytic endopeptidase complex beta chain; AltName: Full=Proteasome beta chain; AltName: Full=Proteasome chain 3; Short=HsN3; Flags: Precursor;. Gene name Name=PSMB4 Synonyms=PROS26 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0535: pI=5.45; Mw=24205 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0824: pI=5.46; Mw=23316 Cross-references UniProtKB/Swiss-Prot P28070; PSB4_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSB4_HUMAN Primary accession number P28070 Secondary accession number(s) B2R9L3 P31148 Q5SZS5 Q6IBI4 Q969L6 Sequence was last modified on  October 17, 2006 (version 4) Annotations were last modified on  March 15, 2017 (version 193) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-4; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=26 kDa prosomal protein; Short=HsBPROS26; Short=PROS-26; AltName: Full=Macropain beta chain; AltName: Full=Multicatalytic endopeptidase complex beta chain; AltName: Full=Proteasome beta chain; AltName: Full=Proteasome chain 3; Short=HsN3; Flags: Precursor; Gene name Name=PSMB4 Synonyms=PROS26 Encoded on Name=PSMB4; Synonyms=PROS26 Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Phosphoprotein; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D26600; BAA05647.1; -; mRNA EMBL AK313825; BAG36560.1; -; mRNA EMBL CR456820; CAG33101.1; -; mRNA EMBL BT006917; AAP35563.1; -; mRNA EMBL AL589764; CAI16806.1; -; Genomic_DNA EMBL CH471121; EAW53442.1; -; Genomic_DNA EMBL S71381; AAB31085.1; -; mRNA CCDS CCDS996.1; -; . PIR S08186; S08186; . PIR S45719; S45719; . PIR S50147; S50147; . RefSeq NP_002787.2; NM_002796.2; . UniGene Hs.89545; -; . PDB 4R3O; X-ray; 2.60 A; 2/N=46-262 PDB 4R67; X-ray; 2.89 A; 2/N/b/p=46-262 PDB 5A0Q; EM; 3.50 A; N/b=46-264 PDB 5GJQ; EM; 4.50 A; g/u=1-264 PDB 5GJR; EM; 3.50 A; g/u=1-264 PDB 5L4G; EM; 4.02 A; 4/X=1-264 PDB 5LE5; X-ray; 1.80 A; M/a=46-264 PDB 5LEX; X-ray; 2.20 A; M/a=46-264 PDB 5LEY; X-ray; 1.90 A; M/a=46-264 PDB 5LEZ; X-ray; 2.19 A; M/a=46-264 PDB 5LF0; X-ray; 2.41 A; M/a=46-264 PDB 5LF1; X-ray; 2.00 A; M/a=46-264 PDB 5LF3; X-ray; 2.10 A; M/a=46-264 PDB 5LF4; X-ray; 1.99 A; M/a=46-264 PDB 5LF6; X-ray; 2.07 A; M/a=46-264 PDB 5LF7; X-ray; 2.00 A; M/a=46-264 PDB 5T0C; EM; 3.80 A; AT/BT=2-264 PDB 5T0G; EM; 4.40 A; T=2-264 PDB 5T0H; EM; 6.80 A; T=2-264 PDB 5T0I; EM; 8.00 A; T=2-264 PDB 5T0J; EM; 8.00 A; T=2-264 PDBsum 4R3O; -; . PDBsum 4R67; -; . PDBsum 5A0Q; -; . PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4G; -; . PDBsum 5LE5; -; . PDBsum 5LEX; -; . PDBsum 5LEY; -; . PDBsum 5LEZ; -; . PDBsum 5LF0; -; . PDBsum 5LF1; -; . PDBsum 5LF3; -; . PDBsum 5LF4; -; . PDBsum 5LF6; -; . PDBsum 5LF7; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal P28070; -; . SMR P28070; -; . BioGrid 111665; 97; . DIP DIP-33844N; -; . IntAct P28070; 46; . MINT MINT-1192686; -; . STRING 9606.ENSP00000290541; -; . BindingDB P28070; -; . ChEMBL CHEMBL2364701; -; . MEROPS T01.987; -; . iPTMnet P28070; -; . PhosphoSitePlus P28070; -; . BioMuta PSMB4; -; . DMDM 116242733; -; . DOSAC-COBS-2DPAGE P28070; -; . OGP P28070; -; . REPRODUCTION-2DPAGE IPI00555956; -; . SWISS-2DPAGE P28070; -; . EPD P28070; -; . MaxQB P28070; -; . PaxDb P28070; -; . PeptideAtlas P28070; -; . PRIDE P28070; -; . TopDownProteomics P28070; -; . DNASU 5692; -; . Ensembl ENST00000290541; ENSP00000290541; ENSG00000159377; . GeneID 5692; -; . KEGG hsa:5692; -; . UCSC uc001eyc.2; human; . CTD 5692; -; . DisGeNET 5692; -; . GeneCards PSMB4; -; . HGNC HGNC:9541; PSMB4; . HPA HPA006700; -; . MIM 602177; gene; . neXtProt NX_P28070; -; . OpenTargets ENSG00000159377; -; . PharmGKB PA33886; -; . eggNOG KOG0185; Eukaryota; . eggNOG ENOG410YAMA; LUCA; . GeneTree ENSGT00390000000698; -; . HOGENOM HOG000181719; -; . HOVERGEN HBG018194; -; . InParanoid P28070; -; . KO K02736; -; . OMA RIMRVND; -; . OrthoDB EOG091G0JV7; -; . PhylomeDB P28070; -; . TreeFam TF106220; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMB4; human; . GeneWiki PSMB4; -; . GenomeRNAi 5692; -; . PRO PR:P28070; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000159377; -; . CleanEx HS_PSMB4; -; . ExpressionAtlas P28070; baseline and differential; . Genevisible P28070; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0005839; C:proteasome core complex; ISS:UniProtKB; . GO GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl; . GO GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IEA:Ensembl; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome CDD cd03760; proteasome_beta_type_4; 1; . Gene3D 3.60.20.10; -; 1; . InterPro IPR029055; Ntn_hydrolases_N; . InterPro IPR016050; Proteasome_bsu_CS; . InterPro IPR016295; Proteasome_endopept_cplx_B; . InterPro IPR001353; Proteasome_sua/b; . InterPro IPR023333; Proteasome_suB-type; . PANTHER PTHR11599:SF72; PTHR11599:SF72; 1; . Pfam PF00227; Proteasome; 1; . PIRSF PIRSF001213; Psome_endopept_beta; 1; . SUPFAM SSF56235; SSF56235; 1; . PROSITE PS00854; PROTEASOME_BETA_1; 1; . PROSITE PS51476; PROTEASOME_BETA_2; 1; .

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